About PRALUENT

What is PRALUENT?

In adults with cardiovascular (CV) disease,

PRALUENT is proven to help reduce the risk of having certain CV events

If you have heart disease, and your bad (LDL) cholesterol remains high, you're at risk for a heart event, like a heart attack, stroke, or certain types of chest pain conditions (unstable angina) requiring hospitalization.

Nearly 1 in 3 people who survived a heart attack or stroke suffered another cardiovascular event in the next 4 years.*

*Based on a 4-year follow-up of over 20,000 people who had a prior heart attack or stroke; cardiovascular event is defined as CV death, heart attack, stroke, or rehospitalization.

Who should use PRALUENT?

PRALUENT is an injectable prescription medicine used in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of chest pain conditions (unstable angina) requiring hospitalization.

It is not known if PRALUENT is safe and effective in children.

Every year, on average, almost 800,000 Americans will have a heart attack.

And if you’ve already had a heart attack or a stroke, your risk of another cardiovascular event is 1 in 3.*

*Based on a 4-year follow-up of over 20,000 people who had a prior heart attack or stroke; cardiovascular event is defined as CV death, heart attack, stroke, or rehospitalization.

The higher your bad (LDL) cholesterol levels, the greater your risk of a heart attack, stroke, or certain types of chest pain conditions (unstable angina) requiring hospitalization.

In people who have already had a CV event, as your bad cholesterol levels rise, so does your risk for another CV event. This is typically related to a process called atherosclerosis—a dangerous condition that develops when bad cholesterol combines with other substances in the blood and turns into plaques that build up in your arteries.

As plaque builds up in the artery, it can make it difficult for blood to flow. Like a buildup of cars can cause a traffic jam, plaque can continue to grow until it either blocks an artery or a piece of it can break off and get carried by the bloodstream until it gets stuck in another artery and forms a clot that may rapidly block that artery.

Even if you feel fine, keeping your bad cholesterol in check is an important part of helping to reduce your risk for having a heart attack or stroke.

PRALUENT is an injectable prescription medicine used along with diet, alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia), to reduce low-density lipoprotein cholesterol (LDL-C) or bad cholesterol.

It is not known if PRALUENT is safe and effective in children.

Heterozygous familial hypercholesterolemia (HeFH) is an inherited condition that causes very high levels of bad cholesterol. If left untreated, people with HeFH have a 20x increase in risk for premature heart disease. Unfortunately, most people are unaware they have HeFH until they develop heart disease or suffer a cardiovascular event. This condition is more common than you think.

Approximately 1 in 250 people worldwide have HeFH.

Signs & symptoms of HeFH

Tuberous xanthomas Bumps or lumps that form around the knuckles, elbows, and knees

Xanthelasmas Yellow areas around the eyes

Tendon xanthomas Swollen or painful tendons in hands or feet

Corneal arcus White arc near the iris

Learn more about very high levels of inherited bad cholesterol and if you are at risk.
Download the HeFH brochure.

Download the PRALUENT brochure

Learn how PRALUENT can help people with CV disease reduce the risk of having another heart attack, stroke, or unstable angina.

Know your LDL-cholesterol levels

To help you understand your cholesterol goals, it’s important to know what your bad cholesterol levels mean. Knowing your bad cholesterol levels can help you better manage your cholesterol and know when it may be time to make a change. If your current treatment plan isn’t bringing down your bad cholesterol far enough, ask your doctor about PRALUENT. Use the chart below to talk to your doctor about your cholesterol goals.

Do you know what your LDL-cholesterol level means?

LDL-cholesterol levelRisk level
Less than 70 mg/dLIdeal for patients at very high risk, or with existing heart disease
Less than 100 mg/dLIdeal for patients at high risk, without heart disease
100-129 mg/dLNear ideal if there is no heart disease; high if there is heart disease
130-159 mg/dLBorderline high if there is no heart disease; high if there is heart disease
160-189 mg/dLHigh if there is no heart disease; very high if there is heart disease
190 mg/dL and aboveVery high

Who should not use PRALUENT?

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Click here to download the Full Prescribing Information, which contains a complete list of the ingredients in PRALUENT.

How PRALUENT works

PRALUENT is not a statin. Statins help lower the production of bad cholesterol. PRALUENT works by blocking a protein (called PCSK9) that contributes to high levels of bad cholesterol. Adding PRALUENT helps increase your liver’s ability to clear bad cholesterol from your bloodstream.

Though they work differently, PRALUENT and statins can work together to lower your bad cholesterol when added to a healthy diet. PRALUENT may be used with or without a statin. PRALUENT is an injectable medication called a PCSK9 inhibitor. It is taken every 2 weeks or 4 weeks (monthly). Click here for more information about dosing PRALUENT.

Gina takes PRALUENT. Watch the video to learn how it’s helped her

Talking to your doctor

Communicating with your doctor is an important part of getting good medical care. Use these talking points to help get the conversation about PRALUENT started:

  • How could PRALUENT help lower bad (LDL) cholesterol?
  • How could PRALUENT help reduce the risk of another heart attack or stroke?
  • Are diet and lifestyle changes enough to lower my risk of another heart attack or stroke?
  • Can I take PRALUENT with other medications I’m taking? How does PRALUENT work differently from statins?
  • How long will I need to take PRALUENT?
  • What should I do if I miss a dose?
  • Are there resources available to help me get started with PRALUENT, such as a self-injection training video or financial support?

Download a PDF version you can take to your next doctor visit.

Results with PRALUENT

See how PRALUENT is proven to lower the risk of heart attack, stroke, and certain types of chest pain conditions (unstable angina) requiring hospitalization in adults with CV disease.

What is PRALUENT® (alirocumab)?

PRALUENT is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of chest pain conditions (unstable angina) requiring hospitalization.
  • along with diet, alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia), to reduce low-density lipoprotein cholesterol (LDL-C) or bad cholesterol.

It is not known if PRALUENT is safe and effective in children.

Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before you start using PRALUENT, tell your healthcare provider about all of your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

Tell your healthcare provider or pharmacist about any medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.

PRALUENT can cause serious side effects, including allergic reactions that can be severe and require treatment in a hospital. Stop using PRALUENT and call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, hives, severe itching, trouble breathing or swelling of the face, lips, throat, or tongue.

The most common side effects of PRALUENT include: redness, itching, swelling, or pain/tenderness at the injection site, symptoms of the common cold, and flu or flu-like symptoms. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Talk to your doctor about the right way to prepare and give yourself a PRALUENT injection and follow the “Instructions for Use” that comes with PRALUENT.

You may report side effects to the FDA at 1-800-FDA-1088 or http://www.fda.gov/medwatch.

Please see Full Prescribing Information for PRALUENT.

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Still have questions about PRALUENT? Get answers

FAQs
Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before you start using PRALUENT, tell your healthcare provider about all of your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

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