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Frequently Asked Questions

Get answers to your questions about PRALUENT® (alirocumab) Injection here.

Whether you’re starting PRALUENT or just seeking more information, you’re sure to have questions. These frequently asked questions can provide you with answers.

If you can’t find the information you need here, you can get an answer by calling 1-844-PRALUENT (1-844-772-5836) and speaking to a care specialist or nurse.

About PRALUENT

What is PRALUENT?

PRALUENT is an injectable prescription medicine called a PCSK9 inhibitor. PRALUENT is used along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart problems, who need additional lowering of LDL cholesterol.

The effect of PRALUENT on heart problems such as heart attacks, stroke, or death is not known.

It is not known if PRALUENT is safe and effective in children.

Do I still need to take my cholesterol pills?

Speak to your doctor if you have any questions, and take your medicine as directed.

How does PRALUENT work differently from a statin?

Both PRALUENT and statins are used to lower your bad cholesterol, but they work differently. Statins block your liver from producing cholesterol. PRALUENT works by increasing your body’s natural ability to remove cholesterol from the blood.

Who should not take PRALUENT?

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT. The inactive ingredients in PRALUENT are histidine, polysorbate 20, sucrose, and water. Check with your doctor if you are not sure.

Safety

What are the possible side effects of PRALUENT?

PRALUENT has been generally well tolerated in 9 clinical trials and in over 2000 patients. PRALUENT can cause serious side effects, including:

Allergic reactions. PRALUENT may cause allergic reactions that can be severe and require treatment in a hospital. Call your doctor or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of PRALUENT include: symptoms of the common cold, redness, itching, swelling, or pain at the injection site, and flu or flu-like symptoms.

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of PRALUENT. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088, or www.fda.gov/medwatch.

Are there any drug-drug interactions with PRALUENT?

No typical drug-drug interactions of PRALUENT have been seen with other drugs, however, please tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

Can I take PRALUENT with other medications?

PRALUENT is used with other lipid-lowering medications to treat high cholesterol. Be sure to talk to your doctor about all the medicine you take before you start using PRALUENT.

Can I take PRALUENT if I am pregnant or breastfeeding?

Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It is not known if PRALUENT will harm your unborn baby. Tell your doctor if you become pregnant while taking PRALUENT.

You and your doctor should decide if you will take PRALUENT or breastfeed. You should not do both without talking to your doctor first.

What should I tell my doctor before taking PRALUENT?

Before you start using PRALUENT, tell your doctor about all your medical conditions, including allergies and if you:

Are pregnant or plan to become pregnant. It is not known if PRALUENT will harm your unborn baby. Tell your doctor if you become pregnant while taking PRALUENT.

Are breastfeeding or plan to breastfeed. You and your doctor should decide if you will take PRALUENT or breastfeed. You should not do both without talking to your doctor first.

Tell your doctor or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

PRALUENT delivery

Where do I get PRALUENT?

A specialty pharmacy (SP) can conveniently deliver PRALUENT to you. Or, you may be able to pick it up from your local retail pharmacy. Once you receive PRALUENT, be sure to put it in the refrigerator.

Can I pick up PRALUENT at my local pharmacy?

Yes, you may be able to pick up PRALUENT from your retail pharmacy. Talk to your doctor if you think this method makes more sense for you.

What should I do if I don’t receive my prescription of PRALUENT from the specialty pharmacy?

If your PRALUENT does not arrive on schedule, call the MyPRALUENT® team at
1-844-PRALUENT (1-844-772-5836) and press 1. Our care specialists will work with your specialty pharmacy to make sure you get your medicine.

What happens if I’m not home when my prescription of PRALUENT is delivered?

You do not need to be home to sign for your PRALUENT delivery. PRALUENT will be shipped in a temperature-controlled container that will keep PRALUENT at the correct temperature during transport and delivery to your home. Your supply of PRALUENT will need to be placed in your refrigerator within 24 hours of delivery. If you will not be home the day it is scheduled to be delivered, call your specialty pharmacy. The pharmacy can reschedule the delivery for a day that works for you.

How long can PRALUENT be left out without refrigeration?

PRALUENT should not be left out of refrigeration for longer than 24 hours at room temperature. Do NOT use any PRALUENT that has been left out of refrigeration for longer than 24 hours.

Storing PRALUENT

How should I store PRALUENT?

Keep PRALUENT refrigerated at 36°F–46°F (2°C–8°C) in the outer carton in order to protect from light until you are ready to use it. Do NOT freeze. Do NOT expose to extreme heat. Do NOT shake. Take your PRALUENT Pen out of the refrigerator 30–40 minutes before use so that it can warm up. Do NOT heat the pen to warm it up.

Why does PRALUENT have to warm up to room temperature before use?

PRALUENT should be allowed to warm up to room temperature 30–40 minutes before use. Warming will make the injection feel more comfortable.

Can I still use PRALUENT if it has been out of the refrigerator for longer than 24 hours?

No, do NOT use any PRALUENT that has been left out for more than 24 hours. Call us at 1-844-PRALUENT (1-844-772-5836) and press 1 to ask about appropriate disposal of unused PRALUENT.

How should I keep PRALUENT cool while traveling?

Keep PRALUENT in the original packaging when traveling. Pack PRALUENT in a travel cooler, and put a frozen ice pack into the cooler. This will keep your PRALUENT cool without freezing it. Do not freeze your PRALUENT.

To help you travel with your PRALUENT, we can send you a free travel kit. Order a Travel Kit by calling 1-844-PRALUENT (1-844-772-5836) and pressing 1.

Can I travel on a plane with my PRALUENT?

Check with the airline before traveling with PRALUENT. They can tell you if you may carry your PRALUENT onto the airplane. If allowed, keep PRALUENT in your carry-on. The temperature in the checked luggage area can sometimes be too hot or too cold.

While traveling, it is important that you keep PRALUENT at the correct temperature. If PRALUENT will be out of refrigeration for more than 24 hours, be sure to store PRALUENT in a temperature-controlled travel case.

To help you travel with your PRALUENT, we can send you a free travel kit. Order a Travel Kit by calling 1-844-PRALUENT (1-844-772-5836) and pressing 1.

Be sure to bring any medical documentation to present to airport security. Let the screener know if you have your medicine or a puncture-resistant container in your carry-on.

Taking PRALUENT

How do I take PRALUENT?

See the detailed "Instructions For Use" to learn the right way to prepare and give your PRALUENT injections

  • Use PRALUENT exactly as your doctor tells you to use it. Your doctor will prescribe the dosage that is best for you.
  • If your doctor decides that you or a caregiver can give the injections of PRALUENT, you or your caregiver should receive training on the right way to prepare and administer PRALUENT. Do not try to inject PRALUENT until you have been shown the right way by your doctor or nurse.
  • PRALUENT is injected under the skin (subcutaneously) every 2 weeks or every 4 weeks (monthly).
  • If your doctor prescribes you the monthly dose, you will give yourself 2 separate injections in a row, using a different pen for each injection and two different injection sites.
  • Do not inject PRALUENT together with other injectable medicines at the same injection site.
  • Always check the label of your pen to make sure you have the correct medicine and the correct dose of PRALUENT before each injection.
  • If you forget to use PRALUENT or are not able to take the dose at your regular time, inject your missed dose as soon as you remember, within 7 days. Then, if you inject every 2 weeks take your next dose in 2 weeks from the day you missed your dose or if you inject every 4 weeks take your next dose in 4 weeks from the day you missed your dose. This will put you back on your original schedule.
  • If you missed a dose by more than 7 days and you inject every 2 weeks, wait until your next scheduled dose to re-start PRALUENT or if you inject every 4 weeks, start a new schedule from the time you remember to take your dose. If you are not sure when to re-start PRALUENT, ask your doctor or pharmacist.
  • If you use more PRALUENT than you should, talk to your doctor or pharmacist.
  • Do not stop using PRALUENT without talking with your doctor. If you stop using PRALUENT, your cholesterol levels can increase.

How do I self‐administer the PRALUENT pre‐filled pen?

Learning to use PRALUENT can be easy. Download our step-by-step injection guide, or call 1-844-PRALUENT (1-844-772-5836), and press 1 to speak to a nurse. Please speak with your doctor before using PRALUENT at home.

How often do I need to take PRALUENT?

PRALUENT is given as an injection under the skin (subcutaneously) every 2 weeks or once monthly. For help remembering when to take your next dose, call the MyPRALUENT® team at 1-844-PRALUENT (1-844-772-5836) and press 1

Redness and itching can occur at the injection site after taking PRALUENT. Is that normal?

Red or itchy skin is common after taking PRALUENT. If this does not go away or gets worse, call your doctor right away.

What other supplies do I need to take my PRALUENT injection?

In addition to your PRALUENT Pen, you will need:

  • Alcohol wipes
  • Cotton balls or gauze
  • A puncture-resistant container to dispose of the pen. Medical waste needs to be disposed of in compliance with laws in your area.

To order a sharps disposal container to dispose of your used PRALUENT Pen, call 1-844-PRALUENT (1-844-772-5836) and press 1.

I forgot to take a dose. What should I do?

If you miss an every-2-weeks dose at your regular time, inject PRALUENT as soon as possible within 7 days of the missed dose. You may then resume your regular schedule. If you do not administer the dose within 7 days of your scheduled date, wait until the next dose on the original schedule.

If you miss an every-4-weeks dose, inject as soon as possible within 7 days of the missed dose. You may then resume your original schedule. If you do not administer the missed dose within 7 days, inject the dose immediately and start a new schedule based on the new date.

If you are not sure when to re-start PRALUENT, ask your doctor or pharmacist.

Where on the body should PRALUENT be injected?

Read through the detailed Instructions for Use before you start.

You can use PRALUENT on your:

  • Belly (except the 2-inch area around your navel)
  • Thighs
  • Upper arms

Do NOT use PRALUENT:

  • On sore, tender, bruised, hard, or scarred skin
  • Near a visible vein
  • Together with other injectable medicines at the same injection site

Use a different injection site for the second injection for the monthly 300 mg dose.

What should I do if the needle is bent or pen is damaged?

If the needle or pen is bent or damaged in any way, do not try and fix it. Call the MyPRALUENT® team at 1-844-PRALUENT (1-844-772-5836) and press 1 for further instructions.

Can I reuse the pen?

No, you should NOT reuse the pen. Once you have used the pen, dispose of it in a puncture-resistant container. To order a puncture-resistant container, call 1-844-PRALUENT (1-844-772-5836) and press 1.

Proper Disposal

What do I do with the pen after I inject?

Once you have used the pen, dispose of it in a puncture-resistant container. Do NOT reuse the pen. To order a puncture-resistant container or learn more about proper disposal, call 1-844-PRALUENT (1-844-772-5836) and press 1.

How do I dispose of the used puncture-resistant container once it is full?

Guidelines for how to dispose of sharps disposal containers vary. To learn more about correct disposal in your state, visit www.fda.gov/safesharpsdisposal. Do NOT dispose of your used puncture-resistant container in your household trash unless allowed by local law.

Additional Support

Where can I learn more about PRALUENT?

For more information about PRALUENT, call
1-844-PRALUENT (1-844-772-5836).

Whom should I contact if I have questions about PRALUENT?

The MyPRALUENT® team of nurses and care specialists is here to answer any questions you may have about PRALUENT. Just call us at
1-844-PRALUENT (1-844-772-5836) and press 1.

What is MyPRALUENT® Patient Services?

MyPRALUENT® Patient Services is a tailored program that gives you the support to start and help you stay on PRALUENT—free of charge. We provide:

  • Product use training
  • Programs that may help with the cost of PRALUENT
  • Live nurse support for PRALUENT*
  • PRALUENT tips, tools, and resources

*MyPRALUENT® nurses are available 8:00 AM – 8:00 PM EST, Monday through Friday. A live nurse is also on call 7 days a week.

How can MyPRALUENT® Patient Services help me?

You’re not alone in your efforts to lower your cholesterol. MyPRALUENT® Patient Services offers a wide range of services to help you get started and stay on therapy. With MyPRALUENT® Patient Services you can:

  • Talk live with a nurse to get answers about PRALUENT
  • Learn how to use PRALUENT with training videos or get live help from a nurse*
  • Find programs that may help you with the cost of PRALUENT
  • Get tools to help manage your high cholesterol

*In-home injection training is available by appointment only. Call
1-844-PRALUENT (1-844-772-5836) and press 1, 8:00 AM – 8:00 PM EST, Monday through Friday, to schedule a session with a nurse.

How do I sign up for MyPRALUENT® Patient Services?

Talk to your doctor to sign up for MyPRALUENT® Patient Services. Your doctor will help you fill out the enrollment form. You will need to sign the form for your doctor to enroll you. Or, if you have a prescription, you can sign-up now on this website by clicking the “Sign-up Now” button on the top right hand side of the screen.

Paying for PRALUENT

How much does PRALUENT cost?

The cost of PRALUENT varies based on the type of insurance you have. We can help you find a program to help you with the cost of PRALUENT. For more information, call us at 1-844-PRALUENT (1-844-772-5836) and press 1.

Are there any savings options available?

PRALUENT® is covered by the majority of health insurance and Medicare plans.*

If you have questions about the cost of PRALUENT®, the MyPRALUENT® team can help. When you enroll in MyPRALUENT®, our care specialists will determine if you are eligible for additional support.

If you have private (commercial) insurance

With the MyPRALUENT® Copay Card you may pay $0 per month for your PRALUENT® treatment, subject to an annual cap of $5,500.

If you have government insurance

You may be eligible for assistance programs.

Medicare patients may be eligible for help through the Low Income Subsidy (LIS) program.

If you don’t have insurance or lack pharmacy benefit coverage

The MyPRALUENT® Patient Assistance Program provides PRALUENT® free of charge to eligible patients for up to 12 months. Eligible patients may submit for renewal.

*Formulary data are provided by Managed Markets Insight & Technology, LLC (MMIT) and are current as of March 9, 2017. Because formularies do change and many health plans offer more than one formulary, please check directly with the health plan to confirm coverage.

†Eligible patients with commercial insurance not funded through a government healthcare program subject to an annual cap and other program terms and restrictions. This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicaid, Medicare, VA, DOD, TRICARE, or similar federal or state programs.

Does my health insurance cover PRALUENT?

Our care specialists will work with your doctor to determine if your health insurance covers PRALUENT. For more information, call us at
1-844-PRALUENT (1-844-772-5836) and press 1.

Support to help with your treatment

Find out how you can sign up for MyPRALUENT® Patient Services and get access to resources that may help with starting and staying on PRALUENT.

Learn More

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