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Frequently Asked Questions

Get answers to your questions about PRALUENT® (alirocumab) Injection here.

Whether you’re starting PRALUENT or just seeking more information, you’re sure to have questions. These frequently asked questions can provide you with answers.

If you can’t find the information you need here, you can get an answer by calling
1-844-PRALUENT (1-844-772-5836) and speaking to care specialist or nurse.

About PRALUENT

What is PRALUENT?

PRALUENT is an injectable prescription medicine called a PCSK9 inhibitor. PRALUENT is used along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart problems, who need additional lowering of LDL cholesterol.

The effect of PRALUENT on heart problems such as heart attacks, stroke, or death is not known.

Safety and efficacy in children is unknown.

Do I still need to take my cholesterol pills?

Speak to your doctor if you have any questions, and take your medicine as directed.

How does PRALUENT work differently from a statin?

Both PRALUENT and statins are used to lower your bad cholesterol, but they work differently. Statins block your liver from producing cholesterol. PRALUENT works by increasing your body’s natural ability to remove cholesterol from the blood.

Who should not take PRALUENT?

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT. The inactive ingredients in PRALUENT are histidine, polysorbate 20, and water. Check with your doctor if you are not sure.

Safety

What are the possible side effects of PRALUENT?

PRALUENT has been generally well tolerated in 9 clinical trials and in over 2000 patients. PRALUENT can cause serious side effects, including:

  • Allergic reactions. PRALUENT may cause allergic reactions that can be severe and require treatment in a hospital. Call your doctor or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of PRALUENT include: symptoms of the common cold, redness, itching, swelling, or pain at the injection site, and flu or flu-like symptoms.

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of PRALUENT. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at
1-800-FDA-1088, or www.fda.gov/medwatch.

Are there any drug-drug interactions with PRALUENT?

No typical drug-drug interactions of PRALUENT have been seen with other drugs, however, please tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

Can I take PRALUENT with other medications?

PRALUENT is used with other lipid-lowering medications to treat high cholesterol. Be sure to talk to your doctor about all the medicine you take before you start using PRALUENT.

Can I take PRALUENT if I am pregnant or breastfeeding?

Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

What should I tell my doctor before taking PRALUENT?

Before you start using PRALUENT, tell your doctor about all your medical conditions, including allergies and if you:

  • Are pregnant or plan to become pregnant. It is not known if PRALUENT will harm your unborn baby. Tell your doctor if you become pregnant while taking PRALUENT
  • Are breastfeeding or plan to breastfeed. You and your doctor should decide if you will take PRALUENT or breastfeed. You should not do both without talking to your doctor first
  • PRALUENT has been generally well tolerated in 9 clinical trials and in over 2000 patients

Tell your doctor or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

PRALUENT delivery

Where do I get PRALUENT?

A specialty pharmacy (SP) can conveniently deliver PRALUENT to you. Or, you may be able to pick it up from your local retail pharmacy. Once you receive PRALUENT, be sure to put it in the refrigerator.

Can I pick up PRALUENT at my local pharmacy?

Yes, you may be able to pick up PRALUENT from your retail pharmacy. Talk to your doctor if you think this method makes more sense for you.

What should I do if I don’t receive my prescription of PRALUENT from the specialty pharmacy?

If your PRALUENT does not arrive on schedule, call the MyPRALUENT team at
1-844-PRALUENT (1-844-772-5836) and press 1. Our care specialists will work with your specialty pharmacy to make sure you get your medicine.

What happens if I’m not home when my prescription of PRALUENT is delivered?

You do not need to be home to sign for your PRALUENT delivery. PRALUENT will be shipped in a temperature-controlled container that will keep PRALUENT at the correct temperature during transport and delivery to your home. Your supply of PRALUENT will need to be placed in your refrigerator within 24 hours of delivery. If you will not be home the day it is scheduled to be delivered, call your specialty pharmacy. The pharmacy can reschedule the delivery for a day that works for you.

How long can PRALUENT be left out without refrigeration?

PRALUENT should not be left out of refrigeration for longer than 24 hours at room temperature. Do NOT use any PRALUENT that has been left out of refrigeration for longer than 24 hours.

Storing PRALUENT

How should I store PRALUENT?

Keep PRALUENT refrigerated at 36°F–46°F (2°C–8°C) until you are ready to use it. Take your PRALUENT Pen or PRALUENT Syringe out of the refrigerator 30 – 40 minutes before use so that it can warm up. Do NOT heat the pen or syringe to warm it up.

Why does PRALUENT have to warm up to room temperature before use?

PRALUENT should be allowed to warm up to room temperature 30 – 40 minutes before use. Warming will make the injection feel more comfortable.

Can I still use PRALUENT if it has been out of the refrigerator for longer than 24 hours?

No, do NOT use any PRALUENT that has been left out for more than 24 hours. Call us at 1-844-PRALUENT (1-844-772-5836) and press 1 to ask about appropriate disposal of unused PRALUENT.

How should I keep PRALUENT cool while traveling?

Keep PRALUENT in the original packaging when traveling. Pack PRALUENT in a travel cooler, and put a frozen ice pack into the cooler. This will keep your PRALUENT cool without freezing it. Do not freeze your PRALUENT.

To help you travel with your PRALUENT, we can send you a free travel kit. Order a Travel Kit by calling
1-844-PRALUENT (1-844-772-5836) and pressing 1.

Can I travel on a plane with my PRALUENT?

Check with the airline before traveling with PRALUENT. They can tell you if you may carry your PRALUENT onto the airplane. If allowed, keep PRALUENT in your carry-on. The temperature in the checked luggage area can sometimes be too hot or too cold.

While traveling, it is important that you keep PRALUENT at the correct temperature. If PRALUENT will be out of refrigeration for more than 24 hours, be sure to store PRALUENT in a temperature-controlled travel case.

To help you travel with your PRALUENT, we can send you a free travel kit. Order a Travel Kit by calling
1-844-PRALUENT (1-844-772-5836) and pressing 1.

Be sure to bring any medical documentation to present to airport security. Let the screener know if you have your medicine or a puncture-resistant container in your carry-on.

Taking PRALUENT

How do I take PRALUENT?

  • See the detailed “Instructions for Use” to learn the right way to prepare and give your PRALUENT injections
  • Use PRALUENT exactly as your doctor tells you to use it
  • PRALUENT comes as a single-dose (1 time) pre-filled pen (autoinjector), or as a single-dose pre-filled syringe. Your doctor will prescribe the type and dose that is best for you
  • If your doctor decides that you or a caregiver can give the injections of PRALUENT, you or your caregiver should receive training on the right way to prepare and administer PRALUENT. Do not try to inject PRALUENT until you have been shown the right way by your doctor or nurse
  • PRALUENT is given as an injection under the skin (subcutaneously) 1 time every 2 weeks
  • Do not inject PRALUENT together with other injectable medicines at the same injection site
  • Always check the label of your pen or syringe to make sure you have the correct medicine and the correct dose of PRALUENT before each injection
  • If you forget to use PRALUENT or are not able to take the dose at your regular time, inject your missed dose as soon as you remember, within 7 days of your missed dose. Then, take your next dose 2 weeks from the day you missed your dose. This will put you back on your original schedule. If the missed dose is not given within 7 days, wait until your next scheduled dose to re-start PRALUENT. This will keep you on your original schedule. If you are not sure when to re-start PRALUENT, ask your doctor or pharmacist
  • If you use more PRALUENT than you should, talk to your doctor or pharmacist
  • Do not stop using PRALUENT without talking with your doctor. If you stop using PRALUENT, your cholesterol levels can increase

How do I self‐administer the PRALUENT pre‐filled pen?

Learning to use PRALUENT can be easy. Download our step-by-step injection guide, or call
1-844-PRALUENT (1-844-772-5836), and press 1 to speak to a nurse. Please speak with your doctor before using PRALUENT at home.

How often do I need to take PRALUENT?

PRALUENT is given as an injection under the skin (subcutaneously) 1 time every 2 weeks. For help remembering when to take your next dose, call the MyPRALUENT team at
1-844-PRALUENT (1-844-772-5836) and press 1

Redness and itching can occur at the injection site after taking PRALUENT. Is that normal?

Red or itchy skin is common after taking PRALUENT. If this does not go away or gets worse, call your doctor right away.

What other supplies do I need to take my PRALUENT injection?

In addition to your PRALUENT Pen or Syringe, you will need:

  • Alcohol wipes
  • Cotton balls or gauze
  • A puncture-resistant container to dispose of the pen or syringe. Medical waste needs to be disposed of in compliance with laws in your area.

To order a sharps disposal container to dispose of your used PRALUENT Pen or PRALUENT Syringe, call 1-844-PRALUENT (1-844-772-5836) and press 1.

I forgot to take a dose. What should I do?

If you forget to use PRALUENT or are not able to take the dose at your regular time, inject your missed dose as soon as you remember, within 7 days of your missed dose. Then, take your next dose 2 weeks from the day you missed your dose. This will put you back on your original schedule. If the missed dose is not given within 7 days, wait until your next scheduled dose to re-start PRALUENT. This will keep you on your original schedule. If you are not sure when to re-start PRALUENT, ask your doctor or pharmacist, or call the MyPRALUENT team at 1-844-PRALUENT (1-844-772-5836) and press 1.

Where on the body should PRALUENT be injected?

Read through the detailed Instructions for Use before you start.

You can use PRALUENT on your:

  • Belly (except the 2-inch area around your navel)
  • Thighs
  • Upper arms

Do NOT use PRALUENT:

  • On sore, tender, bruised, hard, or scarred skin
  • Near a visible vein
  • Together with other injectable medicines at the same injection site

What should I do if the needle is bent or the pen is damaged?

If the needle or pen is bent or damaged in any way, do not try and fix it. Call the MyPRALUENT team at
1-844-PRALUENT (1-844-772-5836) and press 1 for further instructions.

Can I reuse the syringe/pen?

No, you should NOT reuse the syringe or pen. Once you have used the syringe or pen, dispose of it in a puncture-resistant container. To order a puncture-resistant container, call
1-844-PRALUENT (1-844-772-5836) and press 1.

Proper Disposal

What do I do with the syringe/pen after I inject?

Once you have used the syringe or pen, dispose of it in a puncture-resistant container. Do NOT reuse the syringe or pen. To order a puncture-resistant container or learn more about proper disposal, call
1-844-PRALUENT (1-844-772-5836) and press 1.

How do I dispose of the used puncture-resistant container once it is full?

Guidelines for how to dispose of sharps disposal containers vary. To learn more about correct disposal in your state, visit www.fda.gov/safesharpsdisposal. Do NOT dispose of your used puncture-resistant container in your household trash unless allowed by local law.

Additional Support

Where can I learn more about PRALUENT?

For more information about PRALUENT, call
1-844-PRALUENT (1-844-772-5836).

Whom should I contact if I have questions about PRALUENT?

The MyPRALUENT team of nurses and care specialists is here to answer any questions you may have about PRALUENT. Just call us at
1-844-PRALUENT (1-844-772-5836) and press 1.

What is PRALUENT Patient Services?

PRALUENT Patient Services is a tailored program that gives you the support to start and help you stay on PRALUENT—free of charge. We provide:

  • Product use training
  • Programs that may help with the cost of PRALUENT
  • Live nurse support for PRALUENT*
  • PRALUENT tips, tools, and resources

*MyPRALUENT nurses are available 8:00 AM – 8:00 PM EST, Monday through Friday. A live nurse is also on call 7 days a week.

How can PRALUENT Patient Services help me?

You’re not alone in your efforts to lower your cholesterol. PRALUENT Patient Services offers a wide range of services to help you get started and stay on therapy. With PRALUENT Patient Services you can:

  • Talk live with a nurse to get answers about PRALUENT
  • Learn how to use PRALUENT with training videos or get live help from a nurse†
  • Find programs that may help you with the cost of PRALUENT
  • Get tools to help manage your high cholesterol

†In-home injection training is available by appointment only. Call
1-844-PRALUENT (1-844-772-5836) and press 1, 8:00 AM – 8:00 PM EST, Monday through Friday, to schedule a session with a nurse.

How do I sign up for PRALUENT Patient Services?

Talk to your doctor to sign up for PRALUENT Patient Services. Your doctor will help you fill out the enrollment form. You will need to sign the form for your doctor to enroll you. Or, if you have a prescription, you can sign-up now on this website by clicking the “Sign-up Now” button on the top right hand side of the screen.

Paying for PRALUENT

How much does PRALUENT cost?

The cost of PRALUENT varies based on the type of insurance you have. We can help you find a program to help you with the cost of PRALUENT. For more information, call us at
1-844-PRALUENT (1-844-772-5836) and press 1.

Are there any savings options available?

We are available to help—no matter your health coverage status. When you enroll, our care specialists will determine if you qualify for programs to help you with the cost of your medicine. Sign-up for PRALUENT Patient Services

Does my health insurance cover PRALUENT?

Our care specialists will work with your doctor to determine if your health insurance covers PRALUENT. For more information, call us at
1-844-PRALUENT (1-844-772-5836) and press 1.

Get the support you need

Find out how you can sign-up for PRALUENT Patient Services and get access to resources that can help with starting and staying on PRALUENT.

Learn More

Find out more about PRALUENT

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