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Understanding cholesterol

The higher your bad (LDL) cholesterol levels are, the greater risk you are at for:

 Heart disease
 A heart attack
 A stroke

PRALUENT® (alirocumab) is used along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart problems, who need additional lowering of LDL cholesterol.

The effect of PRALUENT on heart problems such as heart attacks, stroke, or death is not known.

Bad (LDL) cholesterol is a waxy substance found in your blood. It can build up on the walls of your arteries and form plaque, which leads to health problems.

Even if you feel fine, keeping your bad cholesterol in check is an important part of reducing your risk for developing heart disease or having a heart attack or stroke.

Did you know?

Sometimes, high levels of bad (LDL) cholesterol may be caused by a condition that runs in a person’s family called heterozygous familial hypercholesterolemia, or HeFH. Let your doctor know if someone in your family has been diagnosed with HeFH, or has had a heart attack or stroke at an early age.

Knowing your bad cholesterol number and goal is important. Use the chart below to see where you stand.

LDL cholesterol level Risk level
Less than 70 mg/dL Ideal for patients at very high risk, or with existing heart disease
Less than 100 mg/dL Ideal for patients at high risk, without heart disease
100-129 mg/dL Near ideal if there is no heart disease; high if there is heart disease
130-159 mg/dL Borderline high if there is no heart disease; high if there is heart disease
160-189 mg/dL High if there is no heart disease; very high if there is heart disease
190 mg/dL and above Very high

Talk to your doctor about what your goal number should be, and discuss how to best reach that goal.

Keep in mind that even if you’ve made changes to your lifestyle and tried the highest dose of statin that you can tolerate, you may still need additional treatment.

Cholesterol myths and facts

Do you know which are which?

Myth:
When it comes to heart disease, high levels of bad (LDL) cholesterol do not matter as much as other risk factors, such as diabetes and high blood pressure.
Fact:
Smoking, cholesterol, blood pressure, and diabetes are ALL major controllable risk factors for heart disease, heart attack, and stroke. The more risk factors you have, the greater your risk.
Myth:
Having high levels of bad (LDL) cholesterol can’t hurt you as long as you feel okay.
Fact:
High levels of bad (LDL) cholesterol can lead to the buildup of plaque in the arteries, the most common cause of heart disease, heart attack, and stroke. Plaque buildup most often starts early in life and progresses slowly, with no symptoms. Even if you feel fine, keeping your bad cholesterol levels in check can reduce your risk of plaque buildup.
Myth:
Making healthy changes, such as eating better and exercising more, is all anyone needs to manage cholesterol levels.
Fact:
Healthy lifestyle choices are an important first step toward lowering your risk of heart disease, heart attack, and stroke. However, for some people lifestyle changes may not be enough. If your bad (LDL) cholesterol numbers are still not where they should be, talk to your doctor about your options.

Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before starting PRALUENT, tell your healthcare provider about all your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

PRALUENT can cause serious side effects, including allergic reactions that can be severe and require treatment in a hospital. Call your healthcare provider or go to the nearest emergency room right away if you have any symptoms of an allergic reaction, including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of PRALUENT include: redness, itching, swelling, or pain/tenderness at the injection site, symptoms of the common cold, and flu or flu-like symptoms. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Talk to your healthcare provider about the right way to prepare and give yourself a PRALUENT injection and follow the "Instructions for Use" that comes with PRALUENT.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is PRALUENT® (alirocumab)?

PRALUENT is an injectable prescription medicine called a PCSK9 inhibitor. PRALUENT is used along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL) or atherosclerotic heart problems, who need additional lowering of LDL cholesterol.

The effect of PRALUENT on heart problems such as heart attacks, stroke, or death is not known.

It is not known if PRALUENT is safe and effective in children.

Click here for Full Prescribing Information for PRALUENT.

Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.

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Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before starting PRALUENT, tell your healthcare provider about all your medical conditions, including allergies, and if you
are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

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