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Frequently asked questions

About PRALUENT

PRALUENT is a prescription medication

PRALUENT can be used to help reduce the risk of heart attack, stroke, and certain types of chest pain conditions (unstable angina) requiring hospitalization.

PRALUENT can also be used along with diet, alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including an inherited type of very high cholesterol called heterozygous familial hypercholesterolemia, also known as HeFH), to reduce low-density lipoprotein cholesterol (LDL-C) or bad cholesterol.

It is not known if PRALUENT is safe and effective in children.

In a large clinical study of ~19,000 patients, PRALUENT was proven to reduce the risk of having a heart attack, stroke, or unstable angina requiring hospitalization.

PRALUENT has also been shown to effectively reduce bad cholesterol.

In other clinical studies of patients with heart problems due to plaque in the arteries or with HeFH whose bad cholesterol was not at goal, adding PRALUENT significantly reduced bad cholesterol levels by an average of when taken alone or with other cholesterol-lowering medications and a healthy diet.

PRALUENT is not a statin. Statins help lower the production of bad cholesterol. PRALUENT works by blocking a protein (called PCSK9) that may contribute to high levels of bad cholesterol. Adding PRALUENT helps increase your liver's ability to clear bad cholesterol from your bloodstream.

Though they work differently, PRALUENT and statins can work together to lower your bad cholesterol when added to a healthy diet. PRALUENT can be taken with or without a statin.

PRALUENT Safety Information

PRALUENT can cause serious side effects, including allergic reactions that can be severe and require treatment in a hospital. Call your doctor or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

Common side effects include:

Redness, itching, swelling, or pain/tenderness at the injection site

Symptoms of the common cold

Flu or flu-like symptoms

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of PRALUENT. Ask your doctor or pharmacist for more information. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

It is not known if PRALUENT is safe and effective in children.

PRALUENT can be used in addition to a statin along with other lipid-lowering therapy if needed in order to manage your high cholesterol. Be sure to talk to your doctor about all the medicines you take before you start using PRALUENT.

Before you start using PRALUENT, talk to your doctor if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

It is not known if PRALUENT will harm your unborn baby. Tell your doctor if you become pregnant while taking PRALUENT.

There is a pregnancy registry for women who take PRALUENT during pregnancy. The purpose of this registry is to collect information about your health and your baby’s health. You can talk to your healthcare provider or contact 1-877-311-8972 or go to https://mothertobaby.org/ongoing-study/praluent/ to enroll in this registry or get more information.

You and your doctor should decide if you will take PRALUENT or breastfeed. Do not do both without talking to your doctor first.

Paying for PRALUENT

The cost of PRALUENT will depend on the type of insurance you have.

The MyPRALUENT® Patient Support Program may be able to provide additional information on cost. For more information, call 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist.

You can also click here to visit the MyPRALUENT® page to learn more. 

No matter your insurance coverage, there may be an option to help you with the cost of PRALUENT.

If you have private (commercial) insurance:

  • You may qualify for the MyPRALUENT® Copay Card and pay as little as $0 per month for your PRALUENT treatment, subject to an annual cap of $5,500. Terms and conditions apply*
  • If eligible, you can use this card for PRALUENT copay, coinsurance, and deductibles
APPLY FOR THE COPAY CARD

Eligible patients with commercial insurance not funded through a government healthcare program subject to an annual cap and other program terms and restrictions. This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicaid, Medicare, VA, DOD, TRICARE, or similar federal or state programs.

If you don’t have health or prescription insurance and you meet income restrictions:

  • You may qualify to receive PRALUENT at no cost through the Patient Assistance Support (PASS) Program
  • If eligible, you can get PRALUENT free of charge for up to 12 months
  • If eligible, you may submit for renewal

If you have Medicare Part D insurance that covers PRALUENT and you meet income restrictions, you also may qualify to receive PRALUENT at no cost through the PASS Program.

Call 1-844-PRALUENT (1-844-772-5836) for more information.

Eligible patients subject to program restrictions.

Our care specialists will work with your doctor to determine if your health insurance covers PRALUENT. For more information, call us at 1-844-PRALUENT (1-844-772-5836) and press 1.

The price you pay will depend on your insurance plan. However, this is expected to help with more affordable out-of-pocket costs for most Medicare and cash-paying patients. The new lower list price does not affect the formulation, device, or dosing frequency.

Most Medicare patients can expect to pay between $25 to $150 per month (subject to your individual insurance plan).

Eligible commercially-insured patients still have access to the PRALUENT copay offer, which may bring the copay down to as little as $0ठ(restrictions apply).

You can speak with your pharmacist to see if you can receive PRALUENT at a lower cost as described above.

Eligible patients with commercial insurance not funded through a government healthcare program subject to an annual cap and other program terms and restrictions. This offer is not valid for prescriptions covered by or submitted for reimbursement under Medicaid, Medicare, VA, DOD, TRICARE, or similar federal or state programs.

§Subject to a maximum copay assistance amount from MyPRALUENT® of $5,500 a year.

No. This does not affect product provided under the PASS Program.

Many people with Medicare Part D may not know if they have a drug plan with a coverage gap, commonly referred to as the “donut hole.” This can be a problem because it puts a temporary limit on what gets covered for prescription drugs and related medications. Visit Medicare.gov to learn how you can prepare for the donut hole.

Getting PRALUENT

A specialty pharmacy can deliver PRALUENT to you.

You may be able to pick it up from your local retail pharmacy.

Note: Once you receive PRALUENT, be sure to put it in the refrigerator. After PRALUENT is removed from the refrigerator, it must be used within 30 days or thrown away.

If your PRALUENT pens do not arrive on schedule, you can call your specialty pharmacy or call the MyPRALUENT® team at 1-844-PRALUENT (1-844-772-5836) and press 1. Our care specialists will work with your specialty pharmacy to make sure you get your medicine.

PRALUENT is shipped in a temperature-controlled container to keep it at the correct temperature during transport and delivery to your home. You do not need to sign for your delivery. However, we encourage you to be home if you can so that you can put PRALUENT into your refrigerator as soon as it arrives.

After removal from the refrigerator, if needed, patients may keep PRALUENT at room temperature up to 77°F (25°C) for a maximum of 30 days in its original carton to protect it from light. If you will not be home the day it is scheduled to be delivered, call your specialty pharmacy. The pharmacy can reschedule the delivery for a day that works for you.

If needed, PRALUENT may be left out at room temperature (up to 77°F [25°C]) for a maximum of 30 days. Keep it in its original carton to protect it from light.

After PRALUENT is removed from the refrigerator, it must be used within 30 days or thrown away.

Taking PRALUENT

See the detailed "Instructions for Use" to learn the right way to prepare and give your PRALUENT injections.

If you are not sure how to inject your medicine, know that you are not alone on your road to lower your bad cholesterol levels. Injection support and training are available so you can get started and stay on track. Call 1-844-PRALUENT (1-844-772-5836) and press 1 to speak to a care specialist.

Beyond that, there are a few things to keep in mind:

Learn how to inject at home

  • Do not try to inject PRALUENT until you have been shown how to do so by your doctor or nurse. If your doctor decides that you or your caregiver can give the injections of PRALUENT, he or she should give you training on the right way to do it
  • Use PRALUENT exactly as your doctor tells you to use it. Your doctor will prescribe the dose that is best for you
  • For a refresher on how to inject, check out our How to use PRALUENT page. You can also download the detailed “Instructions for Use”
    (75 mg or 150 mg) to use as a guide

Follow your dosing schedule

  • Depending on your dose, you will inject PRALUENT under your skin every 2 weeks or 4 weeks (monthly)
  • If your doctor prescribes you the monthly dose, you will give yourself 2 separate injections in a row. Use a different pen for each injection, and inject in 2 different spots on your body to avoid irritation
  • If you are taking other injectable medicines along with PRALUENT, do not inject PRALUENT in the same spot that you inject those other medicines
  • Before each injection, check the label of your pen to make sure you have the correct medicine and the correct dose of PRALUENT
  • Click here for instructions on what to do if you miss a dose

Know what to do if you take too much PRALUENT

  • If you use more PRALUENT than you should, talk to your doctor or pharmacist

IMPORTANT: Do not stop using PRALUENT without talking with your doctor. If you stop using PRALUENT, your cholesterol levels can increase.

Your doctor will instruct you to inject PRALUENT under your skin either every 2 weeks or 4 weeks (monthly).

For reminders on when to take your next dose, call the MyPRALUENT® Patient Support Program at 1-844-PRALUENT (1-844-772-5836) and press 1 to speak to a care specialist and sign up for reminder text messages.

Learn more about taking PRALUENT here.

If you are not sure when to restart PRALUENT, ask your doctor or pharmacist.

If your PRALUENT needle or pen is bent or damaged in any way, do not try to fix it. Call the MyPRALUENT® team at 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist for further instructions.

No. You must should NOT reuse your PRALUENT pen. Once you have used the pen, throw it away in a sharps disposal container.

To order your free sharps disposal container, call 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist.

Storing PRALUENT

  • Keep PRALUENT refrigerated at 36°F–46°F (2°C–8°C) in the outer carton in order to protect it from light until you are ready to use it
  • DO NOT freeze PRALUENT
  • DO NOT expose PRALUENT to extreme heat
  • DO NOT shake PRALUENT
  • Take your PRALUENT pen out of the refrigerator 30–40 minutes before you use it so that it can warm up
  • DO NOT heat the pen to warm it up
  • If needed, PRALUENT may be kept at room temperature (up to 77°F [25°C]) for a maximum of 30 days. Keep it in its original carton to protect it from light
  • DO NOT store PRALUENT above 77°F (25°C)
  • After PRALUENT is removed from the refrigerator, it must be used within 30 days or thrown away

Keep PRALUENT and all medicines out of the reach of children.

No. DO NOT use any PRALUENT pens that have been left out of the refrigerator for more than 30 days.

Call the MyPRALUENT® team at 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist and ask how to properly dispose of your unused PRALUENT. 

Keep PRALUENT and all medicines out of the reach of children.

Check with your airline before you travel with PRALUENT. They can tell you if you may carry PRALUENT onto the airplane.

If you are allowed, keep PRALUENT in your carry-on. The temperature in the checked luggage area can sometimes be too hot or too cold.

Be sure to bring your PRALUENT medical documentation to show to airport security. Let the screener know if you have your medicine or a sharps disposal container in your carry-on.

To help you travel with PRALUENT, we can send you a free travel kit. To order one, call 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist.

Proper disposal

Once you have used your PRALUENT pen, throw it away in a sharps disposal container. DO NOT reuse the pen.

To order a sharps disposal container or learn more about how to get rid of used pens, call 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist.

Guidelines on what to do with full sharps disposal containers vary. To learn more about rules in your state, visit www.fda.gov/safesharpsdisposal. DO NOT throw away your used sharps disposal container in your household trash unless allowed by local law.

Additional support

You can talk to your doctor or contact the MyPRALUENT® Patient Support team with any questions you may have about PRALUENT. Just call us at 1-844-PRALUENT (1-844-772-5836) and press 1 to speak with a care specialist.

The MyPRALUENT® Patient Support Program is dedicated to helping you along your PRALUENT journey. Sign up for:

Savings and support options

MyPRALUENT® nurse support over the phone||

PRALUENT tips, tools, and resources to help manage your high cholesterol

||MyPRALUENT® nurses are available by phone 7 days a week, Monday to Friday 8:00 AM to 11:00 PM EST and Saturday to Sunday 8:00 AM to 8:00 PM EST.

There are three ways to sign up for MyPRALUENT®:

  • If you already have a prescription, sign up online here
  • You can also sign up by calling 1-844-PRALUENT (1-844-772-5836) 7 days a week, Monday to Friday 8:00 AM to 11:00 PM EST and Saturday to Sunday 8:00 AM to 8:00 PM EST

OR

  • You can sign up at your doctor’s office when he or she prescribes you PRALUENT. Ask about the MyPRALUENT® Patient Support Program, and your doctor can help you fill out the enrollment form

Don’t yet have a prescription? You can still call us with questions about MyPRALUENT®!

Questions about PRALUENT?

Call 1-844-PRALUENT (1-844-772-5836) and press 1 to speak to a care specialist.

Available 7 days a week, Monday to Friday 8:00 AM to 11:00 PM EST and Saturday to Sunday 8:00 AM to 8:00 PM EST.

What is PRALUENT® (alirocumab)?

PRALUENT is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of chest pain conditions (unstable angina) requiring hospitalization.
  • along with diet, alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia), to reduce low-density lipoprotein cholesterol (LDL-C) or bad cholesterol.

It is not known if PRALUENT is safe and effective in children.

Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before you start using PRALUENT, tell your healthcare provider about all your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

PRALUENT can cause serious side effects, including allergic reactions that can be severe and require treatment in a hospital. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of PRALUENT include: redness, itching, swelling, or pain/tenderness at the injection site, symptoms of the common cold, and flu or flu-like symptoms. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Talk to your doctor about the right way to prepare and give yourself a PRALUENT injection and follow the "Instructions for Use" that comes with PRALUENT.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Click here for Full Prescribing Information for PRALUENT.

Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.

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Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before you start using PRALUENT, tell your healthcare provider about all your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

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