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Inherited condition (HeFH)

What is heterozygous familial hypercholesterolemia (HeFH)?

HeFH is a genetic condition that causes very high levels of bad (LDL) cholesterol. Those affected inherit a specific gene mutation from one of their parents. This gene mutation prevents their body from removing excess bad cholesterol from the body. People with a family history of high bad cholesterol and cardiovascular disease may also have HeFH themselves.

The condition is more common than you think.

Approximately 1 in 250 people worldwide have HeFH

Download the HeFH brochure

Learn more about very high levels of inherited bad cholesterol and if you are at risk.

Have you inherited very high levels of bad cholesterol?

It’s important to let your doctor know if someone in your family has been diagnosed with HeFH or has had a heart attack or a stroke at an early age. If you have HeFH, it was passed on to you by one of your parents. Traditional treatment plans like statins alone and lifestyle changes may not be enough but there are additional treatments available.

The best place to start is to check your current LDL number. HeFH can be diagnosed based on a blood test and a family history.

Symptoms of HeFH

  • Tuberous Xanthomas
    Bumps or lumps that form around the knuckles, elbows, and knees
  • Tendon Xanthomas
    Swollen or painful tendons in hands or feet
  • Xanthelasmas
    Yellow areas around the eyes
  • Corneal Arcus
    White arc near the iris

HeFH and Your LDL Number

Knowing your LDL number is a crucial part of your treatment plan. Use this chart below to talk to your doctor about your goals and your treatment options. The higher your bad cholesterol levels are, the greater risk you are at for experiencing a heart event (such as a heart attack or stroke).

LDL cholesterol level Risk level
Less than 70 mg/dL Ideal for patients at very high risk, or with existing heart disease
Less than 100 mg/dL Ideal for patients at high risk, without heart disease
100-129 mg/dL Near ideal if there is no heart disease; high if there is heart disease
130-159 mg/dL Borderline high if there is no heart disease; high if there is heart disease
160-189 mg/dL High if there is no heart disease; very high if there is heart disease
190 mg/dL and above Very high

For patients with HeFH, clinical studies have shown that PRALUENT lowered bad cholesterol up to 47% on average at 24 weeks when taken with other cholesterol-lowering medicines and a healthy diet.

PRALUENT works differently from a statin.

Statins help lower the production of bad cholesterol. PRALUENT works to increase your liver's ability to clear bad cholesterol from your bloodstream.

Even though PRALUENT is not a statin, they can work together to help lower your bad cholesterol when added to a healthy diet.

Talk to your doctor

Be prepared for your next doctor visit. Fill out a short form to get your customized HeFH guide with questions to discuss with your doctor.

What is PRALUENT® (alirocumab)?

PRALUENT is an injectable prescription medicine used:

  • in adults with cardiovascular disease to reduce the risk of heart attack, stroke, and certain types of chest pain conditions (unstable angina) requiring hospitalization.
  • along with diet, alone or together with other cholesterol-lowering medicines in adults with high blood cholesterol levels called primary hyperlipidemia (including a type of high cholesterol called heterozygous familial hypercholesterolemia), to reduce low-density lipoprotein cholesterol (LDL-C) or bad cholesterol.

It is not known if PRALUENT is safe and effective in children.

Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before you start using PRALUENT, tell your healthcare provider about all your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

Tell your healthcare provider or pharmacist about any prescription and over-the-counter medicines you are taking or plan to take, including natural or herbal remedies.

PRALUENT can cause serious side effects, including allergic reactions that can be severe and require treatment in a hospital. Call your healthcare provider or go to the nearest hospital emergency room right away if you have any symptoms of an allergic reaction including a severe rash, redness, severe itching, a swollen face, or trouble breathing.

The most common side effects of PRALUENT include: redness, itching, swelling, or pain/tenderness at the injection site, symptoms of the common cold, and flu or flu-like symptoms. Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Talk to your doctor about the right way to prepare and give yourself a PRALUENT injection and follow the "Instructions for Use" that comes with PRALUENT.

You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Click here for Full Prescribing Information for PRALUENT.

Click here to learn more about Sanofi's commitment to fighting counterfeit drugs.

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Important Safety Information

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

Before you start using PRALUENT, tell your healthcare provider about all your medical conditions, including allergies, and if you are pregnant or plan to become pregnant or if you are breastfeeding or plan to breastfeed.

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